* Health Benefits of Vitamin D

(NaturalNews) This once obscure vitamin has been thought to only fortify skeletal structure through the minerals calcium and phosphorous; however, new emerging research shows this vitamin carries many more tasks than just strengthening bones.

Vitamin D and Pre-eclampsia

Pre-eclampsia is a devastating systemic disorder that is characterized by proteinuria (protein in urine), high blood pressure, and edema. This disorder can cause grave health problems for the mother and fetus: pre-eclampsia can cause premature delivery and is the leading cause of maternal and infant illness and death around the globe (causing some 76,000 deaths per year). Pre-eclampsia is, no doubt, a problem that greatly affects mothers and infants. The cause still remains unknown; however, a study carried out by the University of Pittsburgh found that vitamin D deficiency early in gestation is associated with a five-fold increase risk of developing pre-eclampsia.

Vitamin D and Diabetes

Most people in Western societies are familiar with diabetes, particularly that of type II diabetes. Type II diabetes is highly publicized since most diabetes sufferers are afflicted with this particular form of the affliction. However, the smaller subset, those suffering with type I diabetes, have a small advantage over their counter parts. Recent research has demonstrated that those who receive high amounts of vitamin D during childhood have a lower risk of developing type I diabetes later on in life, the greater the amount of vitamin D, the greater the benefit.

Type I diabetes is different than type II in the fact that, it does not arise out of insulin resistance; rather, it comes about because the insulin producing beta cells in the pancreas are destroyed by one's own immune system, starting early in childhood. Though more commonly found amongst Europeans and North Americans, it can affect people from all walks of life.

Vitamin D and Cancer

Vitamin D has also been linked to better outcomes in cancer. In breast, colon and prostate cancer, the sun-shine vitamin has been shown to suppress cancer growth and the formation of blood vessels that feed cancer cells. Furthermore, in a breast cancer study, 24 percent in the breast cancer study had adequate levels of the vitamin at the time of diagnosis. Those who were deficient were more likely to have the cancer metastasize or recur ten years later. Moreover, 73 percent of the deficient were more likely to die.

A study in the International Journal of Cancer found that vitamin D protects cells from oxidative stress. This study used the most biologically active form of the vitamin, vitamin D3 along with nonmalignant human prostate epithelial cells. Metabolism of cells produces free radicals that can damage DNA and contribute to cancer formation and accelerated aging. Vitamin D links with a gene that increases its activity and produces an enzyme that combats free radical damage by clearing the cell of those DNA-damaging substances. This relieves cell stress and retains healthy cells.

Vitamin D and Brain Function

Because of the many vitamin D receptors in the brain, it has been discovered that vitamin D plays a very important role in maintaining and achieving a healthy mind. Though more research in this particular area of vitamin D functions is needed, it is worth mentioning since vitamin D has been indicated in children with brain dysfunction (its exact mechanisms are still unclear at present).

Though behavioral and cognitive difficulties and their association to low vitamin D levels is still a little sketchy, what is known is how low vitamin D levels affect depression in the elderly. Accompanied by an overactive parathyroid, low vitamin D levels have been implicated to increase depression in older adults, and in other mental disorders. This information is particularly important because, instead of treating patients with dangerous psychotropic medications that have hazardous side effects, depression could in the future be treated with a higher intake of vitamin D or more calcium and exposure to sunlight.

Supplementation

Now that many of the health benefits of vitamin D have been shown, it is time to describe where to find this vitamin and who needs it the most. The largest source of this vitamin is the sun. Contrary to popular belief, spending time in the sun daily is not deadly. Though there is such a thing as too much of a good thing, never spending any time in the sun is certainly not the better alternative. Lighter individuals need less time than darker individuals, about 15 minutes in the sun daily. For darker individuals, more time is need than 15 minutes (approximately 30 minutes).

Another source is through diet. Raw milk naturally contains vitamin D, but the largest dietary source
would have to be cod liver oil.

As for who needs vitamin D the most, everybody needs it! However, it has been recently shown that young children and infants tend to be deficient, even though they appear healthy otherwise. Currently, the new info on vitamin D and all its varying abilities has prompted many to deem the recommended daily allowance (RDA) to be far too low -- the highest amount suggested being 600 IU. The Vitamin D Council recommends at least 1,000 IU (or 25 ug/day).

To sum up all this info on supplementing this vitamin: if people get plenty of sunshine, raw milk, and cod liver oil, many would surely reap the benefits of this vitamin.

Overall, vitamin D has been for years underestimated in its abilities and its health benefits. The future only holds more data on how important this vitamin is; therefore, supplementation needs to be more emphasized.

* Diet Rich in Fish

Researchers have found that a diet rich in fish, seafood, and grains -- also called polyunsaturated fats -- is better at preventing heart disease than a diet containing olive oil, nuts, and avocados -- called monounsaturated fats.

Although both types of fats are healthy, people should probably include more of the first than the second in their diet to keep a healthy heart, the scientists say.

Too much cholesterol has long been linked to increasing risks of developing heart disease, but it has been less clear how the various dietary fats -- saturated, monounsaturated and polyunsaturated -- make people susceptible to the disease.

Lawrence L. Rudel and colleagues developed a method to determine the effects of the three types of dietary fats on acyl-coenzyme A, a key molecule involved in the metabolism of fatty acids.

The scientists found that mice fed diets high in saturated and monounsaturated fat showed an increase in acyl-coenzyme A compared to mice fed a diet enriched in polyunsaturated fat. These results suggest that polyunsaturated fat is a more suitable replacement than monounsaturated fat for dietary saturated fat, the scientists concluded.

Article: "Monounsaturated fatty acyl-CoA is predictive of atherosclerosis in human ApoB100 transgenic, LDLr-/- mice" by Thomas A. Bell III, Martha D. Wilson, Kathryn Kelley, Janet K. Sawyer, and Lawrence L. Rudel

* New Disease Fighting Nanoparticles

Ultra-miniature bialy-shaped particles — called nanobialys because they resemble tiny versions of the flat, onion-topped rolls popular in New York City — could soon be carrying medicinal compounds through patients' bloodstreams to tumors or atherosclerotic plaques.

The nanobialys are an important addition to the stock of diagnostic and disease-fighting nanoparticles developed by researchers in the Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN) at Washington University School of Medicine in St. Louis. C-TRAIN's "smart" nanoparticles can deliver drugs and imaging agents directly to the site of tumors and plaques.

The nanobialys weren't cooked up for their appealing shape — that's a natural result of the manufacturing process. The particles answered a need for an alternative to the research group's gadolinium-containing nanoparticles, which were created for their high visibility in magnetic resonance imaging (MRI) scans.

Gadolinium is a common contrast agent for MRI scans, but recent studies have shown that it can be harmful to some patients with severe kidney disease.

"The nanobialys contain manganese instead of gadolinium," says first author Dipanjan Pan, Ph.D., research instructor in medicine in the Cardiovascular Division. "Manganese is an element found naturally in the body. In addition, the manganese in the nanobialys is tied up so it stays with the particles, making them very safe."

The bulk of a nanobialy is a synthetic polymer that can accept a variety of medical, imaging or targeting components. In the July 2008 issue of the Journal of the American Chemical Society the researchers report that targeted manganese-carrying nanobialys readily attached themselves to fibrin molecules, which are found in atherosclerotic plaques and blood clots. Laboratory-made clots then glowed brightly in MRI scans. They also showed that the nanobialys could carry both water-soluble and insoluble drugs.

Pan, who is a research instructor in medicine, played a leading role in the creation of nanobialys and chose the particles' name. "When we looked at the particles with an electron microscope, we saw they are round and flat, with a dimple in the center, like red blood cells, but also a little irregular, like bagels," he says. "I came across the word bialy, which is a Polish roll like a bagel without a hole that can be made with different toppings. So I called the particles nanobialys."

Pan is one of a group of researchers headed by Gregory M. Lanza, M.D., Ph.D., and Samuel A. Wickline, M.D. Lanza is an associate professor of medicine and biomedical engineering. Wickline is a professor of medicine, physics, biomedical engineering and cell biology and physiology. Lanza and Wickline are Washington University cardiologists at Barnes-Jewish Hospital.

Nanoparticles can be a more effective way to administer medications and imaging contrast agents because they are targeted, packaged units — drugs and imaging agents stay on the nanoparticles, which can be made to concentrate at a specific site in the body.

In animal studies, the research group has shown that their original, spherical nanoparticles can carry therapeutic compounds to tumors and atherosclerotic plaques. These nanoparticles also can hold thousands of molecules of gadolinium, which allows the researchers to use standard MRI scanning equipment to see where the nanoparticles congregate. The scans can then detect the size of lesions as well as the effect of drugs delivered by the nanoparticles.

But gadolinium has recently been linked to nephrogenic systemic fibrosis (NSF). First described in 2000, NSF is an unusual progressive, incurable disease seen in about 3 percent of patients with severe kidney disease who have had MRI scans using gadolinium. In NSF, collagen accumulates in tissues causing skin hardening and thickening, joint stiffening that can lead to physical disability, and disorders of the liver, lungs, muscles and heart.

"Even though it seems that gadolinium affects only those with severe renal failure, physicians have decided not to use gadolinium even in those with moderate renal failure," Lanza says. "A lot of patients with diabetes or hypertension develop renal failure, so that decision potentially affects many people. Our goal has always been that our nanoparticle technology should be able to help everyone. And with a growing number of people having diabetes and related cardiovascular problems, we knew we needed to find a substitute for gadolinium-based particles — nanobialys are our first step in that direction."

The researchers will continue to adapt the nanobialys for a variety of medicinal applications and work to develop other types of nanoparticles so that they can supply a wide range of medical needs.

"We're not sitting in the lab generating nanoparticles and then looking for what they could be used for," Lanza says. "We see a medical problem and ask what kind of particle might overcome it and then try to create it."

Funding from National Institutes of Health and the National Cancer Institute supported this research.

* How Viruses Evade Immune System

Viral Cloaking Device: How Viruses Evade The Immune System

Viruses achieve their definition of success when they can thrive without killing their host. Now, biologists Pamela Bjorkman and Zhiru Yang of the California Institute of Technology have uncovered how one such virus, prevalent in humans, evolved over time to hide from the immune system.
The human immune system and the viruses hosted by our bodies are in a continual dance for survival--viruses ever seek new ways to evade detection, and our immune system devises new methods to hunt them down. Human Cytomegalovirus (HCMV), says Bjorkman, Caltech's Delbrück Professor of Biology and a Howard Hughes Medical Institute (HHMI) Investigator, "is the definition of a successful virus--it thrives but it doesn't affect the host."

HCMV is carried by eight in 10 people. Although it generally harms only those who are immunocompromised, it has also been linked with brain tumors like the one for which Ted Kennedy recently had surgery. Understanding how HCMV survives may help in the development of a vaccine, as well as in the fight against other viruses with similar evasive tactics.

"We are interested in mechanisms taken by viruses to escape our immune system," says Caltech biology postdoc and HHMI associate Zhiru Yang. She and Bjorkman published their findings on HCMV survival mechanisms in the July 15 edition of Proceedings of the National Academy of Sciences. They describe the underpinnings of a viral cloaking device, partly made of stolen goods from healthy cells, that helps HCMV to move undetected through the body.

For 20 years, Bjorkman's lab has been dedicated to understanding class 1 major histocompatibility complex (MHC) proteins and the immune response, most recently related to AIDS research. MHC proteins carry peptides, small pieces that are chopped up from the cell's internal proteins, to the cell's surface. If a cell has been infected, MHC presents viral peptides to signal T cells to kill it. So some viruses evolved to evade T cells by keeping MHC from reaching the cell surface. In turn, the immune system recruited other hunters to search for cells that don't show MHC proteins.

Sometime along its treacherous evolutionary path, HCMV stole a class 1 MHC molecule from its host and modified it for supreme stealth. "This is a decoy," Bjorkman says. She and Yang analyzed the structure of the mimic, called UL18, to compare how similar it is to the real thing. They found that despite a mere 23 percent match in genetic sequences, UL18 looks almost exactly the same as a true class 1 MHC.

The same immune cells that search for missing MHC proteins are designed to bind to them when they find them, thereby inhibiting an immune response. Yang and Bjorkman found that UL18 happens to bind 1,000 times tighter to these inhibitory receptors than real MHC molecules do. "This is exactly what the virus wants--to avoid being recognized by T cells, but to engage inhibitory receptors to turn off immune cells," Yang notes. "Only a small number of UL18 molecules are required to have the same inhibitory effect as a large number of MHC class I molecules."
"What I find astounding is that the virus stole this gene and kept it almost identical but improved upon its binding," Bjorkman says.

UL18 didn't stop there. "It also binds peptides--that's unique to this MHC mimic. We don't know why," Bjorkman adds. The peptide is obscured from killer cells by yet another shield, Yang says. In a trait it shares with HIV proteins, HCMV's UL18 covers itself with carbohydrates, which are unrecognizable to the immune system. A real class 1 MHC molecule has one site for adding carbohydrates; the fake has 13, Bjorkman notes. The only place where it's not covered is where it binds to the inhibitory receptor.

All its efforts have made UL18 virtually undetectable. "It's a good example of a viral protein that evolved from its host ancestor to block unwanted interactions," Yang says. "The more we understand that, the more effectively we can fight viruses that hide out," Bjorkman adds.
This study was supported by HHMI.

* Cleaning Infected Blood

Biologists Develop Machine To Remove Viruses From Blood

Infectious disease experts designed a machine called the hemopurifier. It works much like a dialysis machine, using thin fibers to capture and remove viruses from the blood it filters. The machine requires the drawing of blood through an artery, which is sent through a tube into the machine, then back into the body. It can treat a number of illnesses.

Every day, 14,000 people are infected with HIV, the virus that leads to AIDs. There's no cure, but now a breakthrough -- a machine that could clean blood, keeping more and more people alive longer.

"I remember lying in bed thinking, 'I am going to die. I'm going to die. I feel so sick.' And I remember thinking laying in that bed, 'And I know exactly what it is,'" HIV patient John Paul Womble, told Ivanhoe. HIV could kill Womble. He watched his father die from the virus and now he is living the rest of his life with it. "I've got to live as healthy as I can, but this virus is not going to control me," he says. Now, a machine could help clean Womble's infected blood and keep him healthier, longer.

"It's designed to mimic the natural immune response of clearing viruses and toxins before cells and organs can be infected," Jim Joyce chairman and CEO of Aethlon Medical in San Diego, told Ivanhoe. Developed by infectious disease and biodefense experts, the hemopurifier works like a dialysis machine. Antibodies on these spaghetti-like fibers capture and remove viruses as blood filters through it.

"Your entire circulation flows through the cartridge about once every eight minutes," Joyce explains. The entire process takes less than a few hours. It could help patients infected with HIV, hepatitis C, as well as people with the measles, mumps and the flu. "The cartridge is able to selectively capture viruses."

A larger version of the machine would be used in a hospital, but a smaller one could be taken to emergencies. It could be a life-safer against the avian flu or bio-weapons like Ebola and small pox, giving people a chance to survive a deadly attack, whether it's from a terrorist or a virus.

"I don't have to be afraid," Womble says. "I have a virus. I've got to do something about that virus. I've got to treat that virus. I've got to live as healthy as I can." The hemopurifier is also a leading treatment candidate to protect United States civilian and military populations from bioterror threats and emerging pandemic threats like the bird flu and dengue fever that are untreatable with drugs and vaccines.

REMOVING VIRUSES FROM BLOOD: The hemopurifier uses antibodies to remove viruses as blood filters through it. It is designed to filter out viruses and toxins before they attack organs. The method is very similar to dialysis, and can be used to help patients with HIV, Hepatitis C, the measles, mumps, the flu, and more. It can also begin working before doctors identify the cause of the illness.

WHAT IS DIALYSIS? Hemodialysis is often used as a treatment for end stage renal disease (ESRD), or kidney failure, in which blood is removed from the body, filtered through an artificial kidney and then the cleaned blood is returned to the body. In the US, hemodialysis is the most common treatment for people who have kidney failure. However, dialysis is also a painful, expensive procedure, and while it cleans the blood well enough to maintain existence, it does little to improve a patient's overall quality of life. Also, data shows that if patients get a transplant before they get to the point of dialysis, they do better in the longer term.
Note: This story originally produced for the American Institute of Physics series

* Alcohol Use Disorders

Alcohol use disorders (AUDs) are frequently overlooked in patients undergoing surgery, say German researchers who studied 1,556 surgical patients.

"First, we noted that AUD is not diagnosed adequately during preoperative assessment. Then, even if a finding of AUD was made before surgery, preventive measures were not often undertaken. This is significant, because patients with AUD have three to four times more complications during and around the time of surgery than patients without AUD," study author Dr. Claudia D. Spies said in a news release issued by the American Society of Anesthesiologists.

When AUD is properly identified, doctors can begin intervention strategies.
Spies and colleagues found that most doctors didn't use well-documented tools for AUD detections, perhaps because the doctors were uncomfortable asking patients about their alcohol consumption.

"Physicians tend to underestimate and miss AUD in younger patients, especially young female patients," Spies said. "Our results emphasize that the use of computer-based screening methods ... applied to every patient, are effective in addressing these biases."

The researchers found that when a computerized self-assessment tool called AUDIT (Alcohol Use Disorder Identification Test) was used, more than twice as many patients with AUD were identified compared to when doctors used the standard preoperative interview.

This may be due to the fact that many doctors lack training in preoperative screening for alcohol use and that patients prefer the more anonymous nature of the computerized self-test.

"Patients seem to be more confident in answering questions about their alcohol use in a computer-based question-and-answer format," Spies said.

The study was published in the current issue of Anesthesiology.

HealthDay

Copyright (c) 2008 ScoutNews, LLC. All rights reserved.

* HIV Patients Living Longer

Since 1996, the life expectancy of HIV patients in developed countries taking antiviral therapy has increased more than 13 years, and deaths have dropped by almost 40 percent, researchers report.

Despite these gains, life expectancy still falls short by some 20 years, compared with people in the general population. Life expectancy among injection drug users and those who start their treatment late is even shorter.
"People on [antiretroviral therapy] can live a fairly long life," said lead researcher Robert Hogg, from the British Colombia Centre for Excellence in HIV/AIDS in Vancouver. "If they are a woman, they can marry and have a child, and see the child grow up. If they're going to school, they can graduate from university, or they can continue to have a full adult life expectancy."

The report was published in this week's special HIV/AIDS issue of The Lancet.
For the study, Hogg's team collected data on 43,355 HIV patients from Europe and North America who participated in 14 studies. Among these patients, 18,587 started treatment in 1996 to 1999, another 13,914 began treatment in 2000 to 2002, and 10,584 started treatment between 2003 and 2005.

During the study period, 2,056 patients died. However, mortality decreased from 16.3 deaths per 1,000 person-years in 1996 to 1999 to 10 deaths per 1,000 person-years in 2003 to 2005. In addition, life expectancy for someone starting treatment at age 20 increased more than 13 years, from 56.1 years in 1996 to 1999 to 69.4 years in 2003 to 2005, the researchers found.

For some HIV patients, life expectancy is even shorter. For example, those who start treatment later in disease progression, life expectancy is 52.4 years, compared with 70.4 years for patients treated early. In addition, life expectancy among injection drug users is also lower at 52.6 years, compared with people who acquired HIV is another way at 64.7 years.

In addition, women had a longer life expectancy compared with men (64.2 versus 62.8 years). This may be due to women starting their treatment earlier, Hogg's group suggests.

"This sort of a mind shift for people, even physicians and researchers, that when you look at this life expectancy for these people is even longer than expected," Hogg said.

Rowena Johnston, vice president for research at the Foundation for AIDS Research, thinks that antiretroviral treatment has transformed HIV/AIDS from an early death sentence to a manageable chronic illness.

"One of the most striking successes of HIV/AIDS research has been the development of antiretroviral therapy that significantly extends the lives of people living with HIV," Johnston said.

Increasingly longer life expectancy is obviously a boon to patients and doctors, but it comes with increased risk of side effects and other difficulties associated with taking these medications for long periods of time, Johnston said. "Clearly, though, the benefits outweigh the risks," she added.

"Longer life expectancies are shifting what has been the traditional portrait of AIDS, such as body-wasting along with numerous rare infections, into a condition that is increasingly associated with some of the manifestations we traditionally think of with older age, like cancers, heart disease, kidney and liver disease, and insulin resistance," Johnston said.
However, Johnston thinks that many HIV patients continue to fall through the cracks. "What we haven't managed to do as well is to increase numbers of people getting tested, so that they find out about their HIV infection early enough to reap these benefits," she said.

HealthDay

Copyright (c) 2008 ScoutNews, LLC. All rights reserved.

* Latest Spine Surgery from India

*
Latest technique of Spine Surgery now available in India
Health & Medicine

Press release from: Forerunners Healthcare Consultants

(openPR) - Forerunners Healthcare Consultants-is a medical tourism company of India. They arrange medical trips to India for the health seeking individual who seeks low cost surgery in India. Percutaneous pedicle screw fixation surgery is first-of-its-kind spine surgery in the India have been launched by Forerunners Healthcare-The pioneers of Medical and Health Tourism to India. This technology is available in just few centers of the world and will be now available in India as well.

This percutaneous pedicle screw fixation surgery has drastically reduced the trauma and morbidity of the patient. The smaller incisions have also ensured lesser chances of getting infections. The two-hour surgery will come with no additional cost to the patient in India.

Percutaneous pedicle screw fixation surgery is first-of-its-kind spine surgery in India. Instead of making a 10-inch incision in the back to fix the screws, the Percutaneous pedicle screw fixation surgery has been performed by making four small incisions, each not more than 1.5 inch long, by using indigenous surgical equipment.

Previously such surgeries were performed by opening the spinal area by making a long incision and then fixing the screws in the area around the spinal cord, which is was more than 9 mm in size. In, a percutaneous pedicle screw fixation surgery small incision is made in the back, and then wires are put in and the screws are introduced. In the absence of any big cut in the back, the view of the area where the screws had to be fixed is available only through X-ray imaging. The surgery has to be performed by constantly looking at the X-ray monitor.The innovative surgical procedure had turned out to be a boon for those who have been suffering for Back pain for a long time.

“Spine Surgery in India could be highly beneficial due to highly reduced costs and extremely good medical care available. Medical tourism is the term coined which covers patients traveling across the globe for tourism purposes clubbing their requirements for treatment of acute illness, elective surgeries such as low cost spine surgery. Spine surgery in India offers some of the best facilities combined with surgeons whose expertise is equal to the best available in any country.

Once in India you can be rest assured about your proper diagnosis and medication. Furthermore, if situation demands, surgery packages are also within your reach. Medical Treatment in India is amid the best in the world, facilitated by the most skilled doctors and up to the minute super sphere hospitals offer.”-said-Dheeraj Bojwani-MD-who is an International patient Consultant for International patients seeking healthcare in India.

For more details on Spine Surgery in India, contact-Dheeraj Bojwani-MD
Web-www.forerunnershealthcare.com
Email- enquiry@forerunnershealthcare.com
Phone-0091-98607-55000

Forerunners Healthcare
Despande Layout, Mumbai.

Web-www.forerunnershealthcare.com
Email- enquiry@forerunnershealthcare.com
Phone-0091-98607-55000

Dheeraj.Bojwani-MD
Pr.forerunners@gmail.com

forerunners healthcare Consultants is the premier most medical tourism company of India aranging medical and health tours for International Patients in India.More than 300 patients has been treated by Forerunners healthcare Consultants.

* Avoid Junk During Pregnancy

Eating Junk While Pregnant Can Harm Your Baby
Article adapted by Medical News Today from original press release.

We all know that smoking and drinking when pregnant can harm the baby, but new research published in The Journal of Physiology suggests that poor diet may also cause long-lasting, irreversible damage in offspring from heart disease to diabetes.

Stéphanie Bayol and Neil Stickland at the Royal Veterinary College, London fed female rats a "junk food" diet of crisps, cheese, muffins and other processed foods throughout pregnancy and lactation.

The offspring, who were overweight at birth, were born with a taste for junk-food themselves. But even when fed a healthy diet, the junk-food babies had a host of medical problems that lasted beyond adolescence into adulthood.

The rats had raised cholesterol and triglyceride levels - both associated with heart disease. Insulin and glucose in the blood were also unusually high, known to be a cause of type-2 diabetes. And the rats remained significantly podgier than normal with extra fat around the kidneys, another diabetes risk-factor.

The female offspring were particularly badly affected, expressing high levels of glucose and the appetite-promoting hormone leptin making them very prone to obesity.

"It seems that a mother's diet whilst pregnant and breastfeeding is very important for the long term health of her child," says Dr Bayol. "This does not mean that obesity and poor health is inevitable and it is important that we take care of ourselves and live a healthy lifestyle. But it does mean that mothers must eat responsibly whilst pregnant."

But will these results translate to humans? Very probably, says Professor Stickland. "Humans share a number of fundamental biological systems with rats, so there is good reason to assume the effects we see in rats may be repeated in humans," he says. "Our research certainly tallies with epidemiological studies linking children's weight to that of their parents."

* How Food Affects The Brain

Studying How Food Affects The Brain

In addition to helping protect us from heart disease and cancer, a balanced diet and regular exercise can also protect the brain and ward off mental disorders.

"Food is like a pharmaceutical compound that affects the brain," said Fernando Gomez-Pinilla, a UCLA professor of neurosurgery and physiological science who has spent years studying the effects of food, exercise and sleep on the brain. "Diet, exercise and sleep have the potential to alter our brain health and mental function. This raises the exciting possibility that changes in diet are a viable strategy for enhancing cognitive abilities, protecting the brain from damage and counteracting the effects of aging."

Gómez-Pinilla analyzed more than 160 studies about food's affect on the brain; the results of his analysis appear in the July issue of the journal Nature Reviews Neuroscience and are available online at

http://www.nature.com/nrn/journal/v9/n7/abs/nrn2421.html.

Omega-3 fatty acids - found in salmon, walnuts and kiwi fruit - provide many benefits, including improving learning and memory and helping to fight against such mental disorders as depression and mood disorders, schizophrenia, and dementia, said Gómez-Pinilla, a member of UCLA's Brain Research Institute and Brain Injury Research Center.

Synapses in the brain connect neurons and provide critical functions; much learning and memory occurs at the synapses, Gómez-Pinilla said.

"Omega-3 fatty acids support synaptic plasticity and seem to positively affect the expression of several molecules related to learning and memory that are found on synapses," Gómez-Pinilla said. "Omega-3 fatty acids are essential for normal brain function.

"Dietary deficiency of omega-3 fatty acids in humans has been associated with increased risk of several mental disorders, including attention-deficit disorder, dyslexia, dementia, depression, bipolar disorder and schizophrenia," he said. "A deficiency of omega-3 fatty acids in rodents results in impaired learning and memory."

Children who had increased amounts of omega-3 fatty acids performed better in school, in reading and in spelling and had fewer behavioral problems, he said.

Preliminary results from a study in England show that school performance improved among a group of students receiving omega-3 fatty acids. In an Australian study, 396 children between the ages 6 and 12 who were given a drink with omega-3 fatty acids and other nutrients (iron, zinc, folic acid and vitamins A, B6, B12 and C) showed higher scores on tests measuring verbal intelligence and learning and memory after six months and one year than a control group of students who did not receive the nutritional drink. This study was also conducted with 394 children in Indonesia. The results showed higher test scores for boys and girls in Australia, but only for girls in Indonesia.

Getting omega-3 fatty acids from food rather than from capsule supplements can be more beneficial, providing additional nutrients, Gómez-Pinilla said.

Scientists are learning which omega-3 fatty acids seem to be especially important. One is docosahexaenoic acid, or DHA, which is abundant in salmon. DHA, which reduces oxidative stress and enhances synaptic plasticity and learning and memory, is the most abundant omega-3 fatty acid in cell membranes in the brain.

"The brain and the body are deficient in the machinery to make DHA; it has to come through our diet," said Gómez-Pinilla, who was born and raised in salmon-rich Chile and eats salmon three times a week, along with a balanced diet. "Omega-3 fatty acids are essential."

A healthy diet and exercise can also reduce the effect of brain injury and lead to a better recovery, he said.

Recent research also supports the hypothesis that health can be passed down through generations, and a number of innovative studies point to the possibility that the effects of diet on mental health can be transmitted across generations, Gómez-Pinilla said.

A long-term study that included more than 100 years of birth, death, health and genealogical records for 300 Swedish families in an isolated village showed that an individual's risk for diabetes and early death increased if his or her paternal grandparents grew up in times of food abundance rather than food shortage.

"Evidence indicates that what you eat can affect your grandchildren's brain molecules and synapses," Gómez-Pinilla said. "We are trying to find the molecular basis to explain this."

Controlled meal-skipping or intermittent caloric restriction might provide health benefits, he said.

Excess calories can reduce the flexibility of synapses and increase the vulnerability of cells to damage by causing the formation of free radicals. Moderate caloric restriction could protect the brain by reducing oxidative damage to cellular proteins, lipids and nucleic acids, Gómez-Pinilla said.

The brain is highly susceptible to oxidative damage. Blueberries have been shown to have a strong antioxidant capacity, he noted.

In contrast to the healthy effects of diets that are rich in omega-3 fatty acids, diets high in trans fats and saturated fats adversely affect cognition, studies indicate.

Junk food and fast food negatively affect the brain's synapses, said Gómez-Pinilla, who eats fast food less often since conducting this research. Brain synapses and several molecules related to learning and memory are adversely affected by unhealthy diets, he said.

Emerging research indicates that the effects of diet on the brain, combined with the effects of exercise and a good night's sleep, can strengthen synapses and provide other cognitive benefits, he added.

In Okinawa, an island in Japan where people frequently eat fish and exercise, the lifespan is one of the world's longest, and the population has a very low rate of mental disorders, Gómez-Pinilla noted.

Folic acid is found in various foods, including spinach, orange juice and yeast. Adequate levels of folic acid are essential for brain function, and folate deficiency can lead to neurological disorders such as depression and cognitive impairment. Folate supplementation, either by itself or in conjunction with other B vitamins, has been shown to be effective in preventing cognitive decline and dementia during aging and enhancing the effects of antidepressants. The results of a recent randomized clinical trial indicate that a three-year folic acid supplementation can help reduce the age-related decline in cognitive function.

In patients with major depression and schizophrenia, levels of a signaling molecule known as brain-derived neurotrophic factor, or BDNF, are reduced. Antidepressants elevate BDNF levels, and most treatments for depression and schizophrenia stimulate BDNF. Here, too, omega-3 fatty acids are beneficial, as is the curry spice curcumin, which has been shown to reduce memory deficits in animal models of Alzheimer's disease and brain trauma. BDNF is most abundant in the hippocampus and the hypothalamus - brain areas associated with cognitive and metabolic regulation.

The high consumption of curcumin in India may contribute to the low prevalence of Alzheimer's disease on the subcontinent.

In humans, a mutation in a BDNF receptor has been linked to obesity and impairments in learning and memory.

"BDNF is reduced in the hippocampus, in various cortical areas and in the serum of patients with schizophrenia," Gómez-Pinilla said. "BDNF levels are reduced in the plasma of patients with major depression."

Smaller food portions with the appropriate nutrients seem to be beneficial for the brain's molecules, such as BDNF, he said.

Gómez-Pinilla showed in 1995 that exercise can have an effect on the brain by elevating levels of BDNF.

He noted that while some people have extremely good genes, most of us are not so lucky and need a balanced diet, regular exercise and a good night's sleep.